First meeting of the

Dutch Virtual Physiological Human Community

January 14, 2011
Location: Turing conference room (Z011), CWI, Sciencepark 123, Amsterdam


room open, coffee/tea

Alex Frangi (UPF, Barcelona) - The Virtual Physiological Human initiative: concept, examples, challenges and opportunities
Nic Smith (St Thomas' Hospital, Kings College London) - Translating biophysical modelling of the heart to the clinic
Hans Hofstraat (Philips Research) - Virtual Physiological Human - MedTech and IT industries enabling more informed clinical decision taking

lunch & opportunity for poster presentations

Joel Bacquet (European Commission) -  The EU vision on the VPH
Frank Gijsen (ErasmusMC) - Shear stress and atherosclerosis in human coronary arteries.
Marielle Bosboom (MUMC) -Clinical application of patient specific wave propagation models for vascular access creation
Louis Vermeulen (AMC) - Modeling Cancer Stem Cells-driven tumour growth

coffee/tea & opportunity for poster presentation

plenary discussion

closing of meeting

The goal of the first VPH-NL meeting is to further build and strengthen the VPH community in the Netherlands by bringing together interested parties and stakeholders from academia, industry and funding agencies. On a global and European scale, VPH research is steadily growing stronger and gaining importance. The European Commission has invested a substantial sum of money in VPH research and plans to continue this support. The establishment of a European VPH Institute is being drafted, that is entirely dedicated to Biomedical Integrative Research. Unfortunately, the Netherlands seems to be underrepresented in these activities and EU-funded VPH projects. Unlike other EU countries, VPH as research topic is also not yet well acknowledged within Dutch national funding agencies. Therefore, the meeting aims to further raise awareness of VPH in the Netherlands and form a VPH-NL working group with the task to further promote VPH research in the Netherlands and beyond.

To participate, please sent an email to Eric Lorenz (e.lorenz at uva.nl) before December 31, 2010. Posters are invited, describing your current VPH related research. If you intend to present a poster during the lunch break, please indicate so, and sent us the poster title


The Virtual Physiological Human (VPH) is a methodological and technological framework that, once established, will enable collaborative investigation of the human body as a single complex system. The collective framework will make it possible to share resources and observations formed by institutions and organisations creating disparate, but integrated structural and functional models of the living human body. This system will enable academic, clinical and industrial researchers to improve their understanding of human physiology and pathology, to derive predictive hypotheses and simulations, develop and test new therapies, with the eventual outcome of better disease diagnosis, treatment and prevention tools in healthcare.

The VPH offers an entirely novel approach to understanding, treating and controlling debilitating diseases, maximizing the return from the vast quantities of patient specific information emerging in the post-genomic era. The progressive advance in computing power and associated information technology offers the potential to deliver tailored clinical treatments based on simulation studies of the individual requiring treatment. We are only now at the very beginning of this new approach; over the next decade we can expect to see substantial advances along these lines in a range of diseases, from cardiovascular disease and cancer to HIV/AIDS and beyond. In the long run, it is the only viable scientific approach to healthcare and medicine.

VPH proposes to re-think the human body holistically, as a single integrated and dynamic system, which operates simultaneously at dramatically diverse space-time scales, from molecules to whole populations, from nanosecond to lifetime through a multidisciplinary approach. Quoting Marco Viceconti: “The vision of integrative biomedical science, shared by a number of distinctly innovative new approaches including systems biology, multiscale modeling, and the physiome, will become practically possible only when an entirely new framework of methods and technologies has been developed for investigating organisms as single systems. This Framework of methods and technologies is called the Virtual Physiological Human.”

Organizing Committee

This meeting is an initiative from, and organized by
Dr. Alfons Hoekstra, UvA
Dr. Maria Siebes, AMC
Prof. Dr. Ed van Bavel, AMC
Prof. Dr. Frans van de Vosse, TUe